Fight Cancer and More with Curcumin
This information is provided for informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease.
Today's News Story:
“Curcumin Can Work On At Least One Dozen Cancers”
Says Dr. Bharat Aggarwal…
Dr. Bharat Aggarwal, who headed the 12-member team of researchers at U.T's M.D. Anderson Cancer Center, said earlier this week that his clinical research has made available not only "the master switch to turn off cancer, but also a cure for it."
"It was already known that Curcumin can prevent cancer," Aggarwal said. "Now it can also be used to cure cancer." And, he added: "We are providing evidence that Curcumin can work on at least one dozen cancers."
"In fact, let's put it this way: we have not found a single cancer on which Curcumin doesn't work," Aggarwal asserted.
Turmeric, whose vernacular name is haldi, is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurvedic, a 5,000-year-old system of medicine that has its origins in India.
Turmeric has long been used as a food preservative, a coloring agent, a spice to flavor food, and as a folk medicine to cleanse the body.
"Because of turmeric's extensive use in foods in India and Pakistan, the incidence of cancer, especially breast, colon, prostate and lung, is a lot less in those countries," Aggarwal said. "And because South Indians use turmeric more widely than North Indians, the prevalence of cancer is less among them than among North Indians," he said.
"The spice has been shown to relieve arthritis as well," he added. The U.T. team's research focused on how Curcumin stops laboratory strains of melanoma from proliferating, and pushes the cancer cells to commit suicide.
The team homed in on a molecule called NF-kappa B, a powerful protein known to promote an abnormal inflammatory response that leads to cancer in some people, arthritis in others, and a wide range of other diseases in other people.
Aggarwal said, "Nearly 98 percent of all diseases are controlled by this molecule. The humble yellow dye can subdue this potent molecule."
Two to five percent of turmeric is Curcumin, and researchers have now found that Curcumin at 95% concentration is far more potent than plain old Turmeric. When combined with Piperine (a black pepper extract) supplements become up to 20 times more potent, a fact that has resulted in the manufacture in the U.S. of a formulation containing 200 capsules each containing 500mg of 95% Curcumin and 3mg of Piperine and sold as a dietary supplement.
Aggarwal said that Indians have known all along about the anti-inflammatory benefits of turmeric, but "there was no documented proof up until now.
Dozens of clinical trials have already begun in the U.S., India, Israel and the U.K., to see if Curcumin also has the same effect on people as it has on the laboratory animals researchers have experimented upon.
The UT findings will be published in the Aug. 15 issue of the journal, Cancer.
What is Curcumin?
Curcumin is a standardized extract of Curcuma Longa root. The active ingredients in Curcuma Longa are a group of plant substances called curcuminoids. Known collectively as "Curcumin," curcuminoids have demonstrated potent antioxidant properties in scientific studies. In the better formulas, there are 200 capsules of 500 mg Curcumin + 3mg Piperine h each bottle.
Curcuminoids are responsible for turmeric's distinctive yellow color, but there can be less than 4% content in turmeric. Advanced Curcumin complexes usually supply 95% total curcuminoids, and Piperine is added as a natural bio-enhancer, to promote absorption of the Curcumin.
Where does it come from?
Native to Southeast Asia, Curcuma longa is a tall tropical shrub. The genus "Curcuma" belongs to the Zingiberaceae family, which includes ginger. The plant possesses a large root structure with fleshy, bulbous underground parts called "rhizomes." These rhizomes, known as turmeric root, are harvested at maturity, dried and cured for commercial use.
Turmeric is named in ancient Ayurvedic and Chinese herbal texts as a traditional folk remedy. Historically, turmeric was used externally for wounds, and sprains, and internally for digestive complaints, rheumatism, liver disorders, coughs and colds.
Nature's Absorption Enhancer Boosts Curcumin Power
Traditional Ayurvedic herbal formulas often include black pepper and long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid, Piperine. Experiments carried out to evaluate the scientific basis for the use or peppers have shown that Piperine significantly enhances bio-availability when consumed with other substances. Several, double blind, clinical studies, have confirmed that Piperine increases absorption of nutrients.
An All Around Herb for General Wellbeing.
Curcumin is the main biologically active part of Turmeric. Over 500 references to articles on Turmeric and Curcumin have been published in peer reviewed professional journals.
It has been identified in pharmacology as:
Turmeric and Curcumin have traditionally also been used to support those suffering from pain and inflammatory conditions:
If that is not enough, Turmeric has been used for thousands of years by Indian women to make their skin beautiful and blemish free.
There are plenty of new studies that show potential benefits with:
The numerous beneficial effects attributed to Turmeric are probably due to the-- antioxidant properties of Curcumin.
Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is a potent "scavenger" of the super oxide radical, a free radical that initiates potentially harmful oxidative processes, such as lipid peroxidation. Through this activity, Curcumin has been shown to protect skin cells from the injurious effect of nitro blue tetrazolium, a toxin that generates super oxide radicals.
Curcumin also increases survival of cells exposed in vitro to the enzyme hypoxanthine/xanthine oxidase, which stimulates super oxide and hydrogen peroxide production, possibly by stimulating the enzyme catalyse.
Curcumin itself is not toxic to cells, even at high concentrations. Because free radicals are involved in aging and exert harmful effects on skin, these results suggest Curcumin may help to slow skin aging.
Curcumin demonstrates several other in vitro effects linked to free radical scavenging.
Curcumin scavenges nitric oxide, a compound that when in excess is associated with the body's inflammatory response.
Pure Curcumin and turmeric extracts protect red blood cells from lipid peroxidation induced by hydrogen peroxide.
Curcumin has been shown to protect DMA from oxidative damage, inhibit binging of toxic metabolites to DNA, and reduce DNA mutations in the Ames test.
Curcumin also demonstrates in vitro inhibition of COX-I and COX-II enzymes, which are involved in the inflammatory reaction.
Together, these results strongly suggest that Curcumin has a potent bio-protective effect, with a potentially wide range of therapeutic applications.
Curcumin is poorly absorbed in the intestinal tract, limiting its therapeutic effectiveness. Oral doses are largely excreted in feces, and only trace amounts appear in; the blood.
Administration of 3 mg of Piperine with 5OOmg of Curcumin (1 capsule) can, in exceptional circumstances, increase the bio availability of Curcumin by 2000%.
We state 100% increase from 5OOmg to the equivalent is about right. Be aware that the bioavailability of all other nutrients taken around the same time (and drugs) may also be increased by the same proportion.
No side effects have been found when taking high doses of Curcumin. Rare cases of stomach upset or diarrhea may be resolved by temporarily reducing the dosage and taking it with food.
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Just a Thought
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